drpen, microneedling, scalp care, Serums, skincare
How to Choose the Best Microneedling Serum – Part 2
Oct
Welcome to Part 2 of the Dr Pen UK Microneedling Serum Guide.
REJUVENATE • ADVANCED REJUVENATION • PLANT EXOSOMES • HAIR & SCALP • RECOVER
In Part 1, we looked at choosing a microneedling serum for four of the most common skincare goals: hydration, firmness, brightness and blemish-prone skin.
Now we’re moving into the next generation of professional skincare.
From PDRN and polynucleotides to exosome technology and specialist scalp formulations, these are some of the most exciting ingredients currently being incorporated into professional microneedling and skin booster treatments.
So, which one should you choose?
🧬 REJUVENATE → PDRN & Polynucleotides
Best for: Mature-looking skin, texture, elasticity and overall rejuvenation
PDRN has rapidly become one of the most talked-about ingredients in professional skincare.
If you’ve moved beyond basic hydration and you’re looking for a more advanced skin booster, PDRN and polynucleotide formulations are an exciting category to explore.
Our Pick: Medisco Meso PDRN
Medisco Meso PDRN combines Sodium DNA with Sodium Hyaluronate, Glutathione, Niacinamide and Adenosine.
The multi-purpose professional formulation is designed for treatments focused on improving the appearance of hydration, texture, elasticity and overall skin quality.
Another Option: REGLORY Reglory PN +
REGLORY PN+ provides another advanced option, combining polynucleotides with Sodium Hyaluronate, Niacinamide and Glutathione.
It is particularly suited to professional rejuvenation treatments where the aim is to achieve smoother, fresher and more revitalised-looking skin.
Choose REJUVENATE if your main concerns are:
- Visible signs of ageing
- Fine lines
- Loss of elasticity
- Uneven-looking texture
- Dry or lacklustre skin
- Overall skin rejuvenation
Our picks: Medisco Meso PDRN or REGLORY PN+
Can’t decide? Explore our PDRN Microneedling Serum Collection to discover and compare several of our popular PDRN and polynucleotide formulations.
🔬 ADVANCED REJUVENATION → Exosomes
Best for: Advanced professional skin rejuvenation
Looking to take your skincare treatment beyond conventional Hyaluronic Acid and peptide formulations?
Exosome-based skincare represents one of the newest categories within advanced professional aesthetics.
Our Pick: Medisco Skin Booster PDRN EXO
Medisco Skin Booster PDRN EXO combines PDRN with grape-derived exosomes, Hyaluronic Acid, AHA and PHA in one advanced formula.
It has been developed to complement professional treatments focused on hydration and improving the appearance of skin texture, elasticity and radiance.
This makes it particularly interesting for experienced users and practitioners looking for something beyond a conventional hydrating ampoule.
Another Option: REGLORY EXO EXOSOME
Combining Human Adipocyte Conditioned Media with ingredients including Niacinamide, Adenosine, Sodium Hyaluronate, Sodium PCA and Betaine.
The formula is designed to support hydration and help improve the appearance of skin texture, radiance and overall vitality. Supplied as a 50mg lyophilised powder with a 6ml activating solution, REGLORY EXO is freshly prepared immediately before professional use.
Choose ADVANCED PROFESSIONAL REJUVENATION if your main concerns are:
- Visible signs of skin ageing
- Loss of elasticity
- Uneven texture
- Dullness
- Dehydration
- Overall skin quality
🌱 PLANT-BASED EXOSOMES → REGLORY EXO+ PLANT
Best for: Customers who want a plant-derived exosome formulation
REGLORY EXO+ PLANT is an advanced professional skin booster powered by plant-derived exosomes extracted from Centella Asiatica.
Centella Asiatica is widely used within advanced skincare and is particularly popular in formulations developed for stressed and compromised-looking skin.
REGLORY EXO+ PLANT has been designed to complement professional treatments targeting the appearance of enlarged pores, uneven texture, dullness, fine lines and loss of elasticity.
It is an exciting alternative for practitioners specifically looking to explore plant-derived exosome technology.
Choose PLANT-BASED EXOSOMES if you want:
- A plant-derived exosome formulation
- Smoother-looking skin
- Improved-looking skin texture
- Greater radiance
- Support for visible signs of ageing
- A professional Centella Asiatica formulation
💆 HAIR & SCALP → REGLORY EXO+ Hair
Best for: Professional scalp and thinning-hair treatments
Microneedling isn’t limited to facial skincare.
The scalp has become an increasingly popular area for professional microneedling treatments and using a formulation specifically developed for scalp care is important.
Our Pick: REGLORY EXO+ Hair
REGLORY EXO+ Hair has been specifically formulated for professional hair and scalp treatments.
The formula contains Human Adipose-Derived Stem Cell Conditioned Media alongside carefully selected ingredients including Caffeine, Sodium Hyaluronate, Sodium PCA and Betaine.
It is designed for professional scalp treatments where the focus is on supporting scalp condition and improving the appearance of thinner, weaker or lacklustre-looking hair.
Choose HAIR & SCALP if your treatment is focused on:
- Thinning-looking hair
- Overall scalp condition
- Dry scalp
- Oily scalp
- Weak or lacklustre-looking hair
- Professional scalp microneedling
🌿 CALM & RECOVER → Post-Microneedling Skincare
Best for: Supporting your skin after treatment
What you use after microneedling deserves just as much consideration as the serum you choose for the treatment itself.
Following microneedling, the focus should move away from complicated skincare routines and towards gentle hydration, skin comfort and supporting the moisture barrier.
Our Picks
Medisco Cica Cream – Ideal for incorporating into an appropriate post-treatment skincare routine.
Stayve Repair Cream – A vegan option for customers looking for supportive skincare following their professional treatment.
Choose CALM & RECOVER if your priorities are:
- Post-treatment hydration
- Supporting the moisture barrier
- Dry or tight-feeling skin
- Maintaining skin comfort
- Keeping your aftercare routine simple
Find Your Microneedling Serum
| Your Goal | Look For |
|---|---|
| 💧 Hydrate | Hyaluronic Acid |
| ✨ Firm | Peptides |
| ☀️ Brighten | Idebenone |
| 🎯 Blemish | AC/BHA |
| 🧬 Rejuvenate | PDRN / Polynucleotides |
| 🔬 Advanced Rejuvenation | Exosomes + PDRN |
| 🌱 Plant-Based | Centella Asiatica Exosomes |
| 💆 Hair & Scalp | REGLORY EXO+ Hair |
| 🌿 Recover | Barrier-Supporting Skincare |
Shop Microneedling Serums at Dr Pen UK
From simple Hyaluronic Acid hydration to advanced PDRN, polynucleotide and exosome skin boosters, choosing your serum according to your main concern can make navigating professional skincare much easier.
Choose your goal. Choose your serum. Elevate your microneedling routine.
Looking for the basics first? Read Part 1: How to Choose the Best Microneedling Serum – Hydrate, Firm, Brighten & Blemish.
Always read the individual product instructions before use. Professional-use products should only be used by appropriately trained practitioners. Microneedling may not be suitable for everyone or every skin condition. Seek professional advice if you are unsure whether a product or treatment is suitable for you.
